Preheat oven to 350 degrees F. Line muffin pans with paper liner or spray with nonstick cooking spray. Set aside 1-1/2 teaspoons of the orange jell-o for the Cream Pop frosting.
In a mixing bowl, beat the remaining jell-o, cake mix, pudding mix, orange juice, eggs, egg substitute, applesauce, and vanilla.
Spoon batter into prepared muffin pans, filling each about 2/3 full, and smooth tops.
Bake for 15-18 minutes or until a toothpick inserted in centers comes out clean. Cool cupcakes in pans on wire rack for 5 minutes; remove from pans and cool completely.